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It may substantially diminish the efficacy of the maintenance treatment. Firstly, it should be noted that such low doses are appropriate only for patients with primary insomnia. The sedative antidepressants may also induce a weight gain, what is particularly shown for mirtazapine but not for trazodone [ 23 ].

Human and Animal Rights and Informed Consent This article does not contain any studies with human or animal subjects performed by any of the authors. One of the groups saline solution [SAL] received i. Although sleep-promoting action is desired in depressed patients with coexisting anxiety or insomnia, it may be problematic during the maintenance treatment after recovery from depression due to oversedation.

Clinical studies have shown that a lower initial dose of MIR i. "Mobile"

Mirtazapine high dose less sedating ssri

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"Mobile" Human and Animal Rights and Informed Consent This article does not contain any studies with human or animal subjects performed by any of the authors. In our opinion, sedative antidepressants are a safe class of drugs when given in low doses. Services on Demand Journal. Some patients show improvement of sleep quality already after the first drug dose [ 15 ], which was specially discussed for mirtazapine as related to the faster onset of antidepressant action [ 16 ].

Disrupted sleep continuity manifests as prolongation of sleep latency, increased number, and duration of awakenings from sleep expressed as increased wake after sleep onset WASO time, decreased sleep efficiency, and early morning awakenings. A decrease occurred only within 20 minutes of administration. This article does not contain any studies with human or animal subjects performed by any of the authors.

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11 thoughts on “Mirtazapine high dose less sedating ssri

  1. Nonetheless, studies with human subjects suggest that MIR-induced sedation is transient, especially when high and repeated doses are used.

  2. The aim of this review article was to summarize recent publications on effects of antidepressants on sleep and to show that these effects not only depend on the kind of antidepressant drugs but are also related to the dose, the time of drug administration, and the duration of the treatment.

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